Dear Colleagues,

We are honored to invite you to the single topic conference on non responders that will be held in Istanbul on 27 to 29 September 2018. Such problems as the exposure of patients to cirrhosis of the liver, and its complications due to the unresponsiveness of chronic hepatitis B, C, and delta infections, to the current treatments; the development of hepatocellular carcinoma; and recurrence of infections following liver transplantation continue to be challenging issues in today’s world. New research with respect to patients with chronic hepatitis and who do not respond, specifically to the treatments specified in the treatment guidelines, will be presented, and interactive discussions will be held with the world’s opinion leaders on hepatology. 

At the same time, the similarities and differences (if any) in terms of treatment between the East and the West will be debated. In particular, the steadily increasing trends in cirrhosis of the liver and hepatocellular cancer rates dependent on the unresponsiveness of the hepatitis C virus, between 2020-2030, will be confronted. For this reason, the treatment of compensated and/or decompensated cirrhosis of the liver being unresponsive or partially responsive to previous treatments or those developing dependent on relapses following treatment will continue to be a globally significant health problem.